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Jan 01, 2020 By developing a high throughput screen for TPH inhibitors, ... 250 and 1000 mg 4 times daily ... A second study using a high-throughput proximity assay screen identified a novel allosteric TPH1-selective inhibitor and disclosed its in vitro and in vivo efficacy Petrassi et al., 2017. Up to now there are no follow-up studies available for both ...

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